Osteoarthritis Under Control: How Cell Therapy Helps Restore Joints

Osteoarthritis, various bone defects, and other orthopedic conditions often cause significant challenges in the daily lives of people of all ages.

These degenerative disorders – in which the cartilage tissue of the joints gradually breaks down – may result from several factors, including:

• age-related changes;
• excessive physical load;
• trauma [1].

Osteoarthritis may sound like a daunting diagnosis – pain, stiffness and limitations in daily activities [2].

But this does NOT mean the end of an active life!

Modern medicine offers an effective solution – cell therapy, which activates the body’s natural regenerative processes.

Innovative treatment with stem cells, known for their restorative and immunomodulatory properties, has become a preferred approach among specialists worldwide.

This method is considered ideal for treating inflammatory diseases of the musculoskeletal system, as it significantly enhances tissue repair and improves patients’ quality of life [3].

Stem cells used in cell therapy are young and undifferentiated, possessing a unique ability to self-renew and transform into various types of cells.
Their main function lies in the clinically proven effectiveness of tissue regeneration and stimulation of healing processes [4].

At ReoCell Clinic, we use highly advanced mesenchymal stem cells (MSCs) for osteoarthritis therapy. These cells demonstrate strong regenerative properties and can modulate immune responses in damaged joint structures. We develop personalized treatment protocols tailored to each individual patient.

Mechanism of Action of Stem Cells

In osteoarthritis, stem cells act through several key mechanisms:

• Direct differentiation into cartilage and other adjacent joint tissues, replacing the damaged ones [5].
• Paracrine (indirect) effects – young and undifferentiated cells secrete bioactive substances such as growth factors and anti-inflammatory molecules that reduce inflammation, stimulate regeneration, improve blood flow, and prevent cell death, thereby slowing joint destruction [5, 6].
• Improvement of blood supply to damaged tissues, ensuring better oxygen and nutrient delivery to joint structures [7].
• Prevention of apoptosis (genetically programmed cell death of mature cartilage cells), which helps protect joint tissues from further degeneration [5].

Clinical Benefits for Patients

The main therapeutic outcomes of bone marrow-derived mesenchymal stem cell (MSC) treatment, which help avoid or delay surgery, include:

• Pain reduction – about 70-80% of patients report significant pain relief within the first few weeks [6, 7].
• Improved joint mobility – 65-75% of patients experience less stiffness and greater ease in daily movements [5, 6].
• Decreased inflammation and swelling – observed in 60-70% of cases [5].
• Cartilage tissue regeneration – MRI and arthroscopy show positive structural changes in 40-50% of patients within several months [6, 7].
• Enhanced quality of life – 75% of patients report returning to an active lifestyle without constant use of painkillers [7].

Why Choose ReoCell Clinic for Stem Cell Therapy in Osteoarthritis Treatment?

Our experienced specialists perform the procedure on an outpatient basis, without surgical intervention or hospitalization. After stem cell administration, patients can return to their normal activities immediately, as no long rehabilitation is required.

Before the procedure, each patient undergoes a thorough assessment by our specialized medical team. The best treatment strategy is determined exclusively based on medical criteria and tailored to your specific condition.

At ReoCell Clinic, your comfort and safety are our priorities.

We adhere to the following principles:

• Comprehensive care. We integrate regenerative therapy with rehabilitation programs, nutrition, and lifestyle recommendations to ensure a holistic approach to joint health.
• Personalized programs. Every treatment plan is created with attention to your individual needs, medical history, and the stage of osteoarthritis.
• Cutting-edge equipment. We follow strict safety protocols to guarantee the highest standard of cell handling and patient care.
• Experienced medical team. Our doctors have extensive experience in stem cell therapy and provide individualized attention to each patient.
• Continuous support. A dedicated clinical consultant accompanies you through every step – from the initial consultation to post-treatment follow-up.

Osteoarthritis is a challenge – but cell therapy and the expertise of our team give you the chance to regain comfort and freedom of movement.

Book a consultation at ReoCell Clinic today and discover whether this treatment is right for you.

References:

1. Kraus VB, Blanco FJ, Englund M, Karsdal MA, Lohmander LS. Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use. Osteoarthritis Cartilage. 2015 Aug;23(8):1233-41.. Epub 2015 Apr 9. PMID: 25865392; PMCID: PMC4516635.
2. Reischl S, Ziebart C, Johnston Z, Ma J, Pham D, Salloum JF, Sithganesan M, Wikkerink S, Munro K, MacDermid JC. Patient Experience of Stiffness With Knee Osteoarthritis: An Interpretative Description Study. Musculoskeletal Care. 2024 Sep;22(3):e1922. PMID: 39073278.
3. Liu T, Ran C, Zhao D, Yang F, Guo Q, Yang J, Zhang X. Mesenchymal stem cells and their exosomes mitigate osteoarthritis by restoring the balance between proinflammatory Teffs and Tregs. Front Aging. 2024 Nov 19;5:1509014. PMID: 39629263; PMCID: PMC11611854.
4. Cao M, Ou Z, Sheng R, Wang Q, Chen X, Zhang C, Dai G, Wang H, Li J, Zhang X, Gao Y, Shi L, Rui Y. Efficacy and safety of mesenchymal stem cells in knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Stem Cell Res Ther. 2025 Mar 7;16(1):122. PMID: 40055739; PMCID: PMC11887158.
5. Sadri B, Hassanzadeh M, Bagherifard A, et al. Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial. Stem Cell Res Ther. 2023;14(1):162.
6. Holiuk Y, Birsa R, Bukreieva T, et al. Effectiveness and safety of multiple injections of human placenta-derived MSCs for knee osteoarthritis: a nonrandomized phase I trial. BMC Musculoskelet Disord. 2025;26:418. PMID: 40281581.
7. Rahmadian R, Ariliusra Z, Kusuma KRA, Ali H, Raymond B, Meksiko R. Efficacy of a single intra-articular injection of mesenchymal stem cells for knee osteoarthritis: a dose-focused meta-analysis of randomized controlled trials. J Orthop Surg Res. 2025 Aug 30;20(1):812. PMID: 40886001; PMCID: PMC12398016.

Back to the blog